John Wayne Casserole (Beef and Biscuit Casserole)

Okay, raise your hand if you LOVE casseroles! My hand is definitely up, I love casseroles. John Wayne casserole (beef and biscuits casserole), is one of a kind with its taco ingredients and biscuit mix. You do NOT want to pass this up.

Honestly, I am not quite sure how this recipe got its name, but I think it’s because John Wayne loved casseroles too!

I know some people aren’t a huge fan of casseroles, but as a mom, I absolutely love them. It’s so nice to be able to throw something together and walk away and get more done while it’s cooking. 

Also, it doesn’t hurt that my kids eat this WITHOUT COMPLAINING! It is a hit in our house. I’ve even considered doubling the batch so I actually get to have some leftovers. That’s another reason casseroles are one of my favorite things to make, who doesn’t love leftovers?

Want to check out some more awesome casserole recipes? Take a look at our homemade green bean casserole without condensed soup, chicken enchilada casserole, and of course our super popular million dollar casserole! Do yourself a favor and bookmark these because you will be making them over and over again!



  1. Ground beef
  2. Taco seasoning mix package
  3. Water
  4. Sour cream
  5. Light mayonnaise
  6. Shredded cheddar cheese
  7. Onion
  8. Bisquick biscuit mix
  9. Green bell pepper
  10. Roma tomatoes
  11. Can of green chilies

If you make a lot of taco recipes you might even consider making your own (maybe even in bulk!) using this taco seasoning recipe from 

Another great recipe to have on hand is this homemade bisquick recipe! You can make your own and save a trip to the store!

If you don’t have light mayonnaise, you can use regular mayonnaise. Miracle whip could also be substituted, but it will give the casserole a little bit different taste.

Other items you’ll need for this beef and biscuit casserole:

  • 9×13 inch baking dish (check THIS one out)
  • Nonstick cooking spray
  • Small mixing bowl
  • Medium mixing bowl
  • Medium-sized pan (similar to THIS

Related Article: Our Korean Beef and Rice is a must if you’re dealing with picky eaters! 


Our most popular cookbook – Dinner Made Easy –  is all about quick, easy, and delicious family dinner entrees. We did all the organization, all the taste-testing with picky kids, and all the hacks to cut the prep time so that you can focus on spending more time with your family.


Every recipe has a beautiful mouth-watering photo and has been picky-eater approved. The directions are simple, easy to follow, and do not require any strange ingredients.

The complete family meal game plan in this cookbook is arranged in seven popular categories: 

30 Minutes or Less including recipes for: Skillet Pork Lo Mein, Parmesan Pork Chops, and Ham and Pineapple Pizza Roll-ups.

5 Ingredients or Less including recipes for: Easy Gnocchi Casserole, Sweet and Tangy Meatballs, and Baked Sloppy Joes.

Pantry Essentials including recipes for: Seven-Can Tortilla Soup, Crispy Coconut Strips with Pina Colada Dipping Sauce and French Dip Crescents.

Slow Cooker including recipes for: Honey Garlic Chicken, Tuscan Soup, and Mongolian Beef.

Freezer Meals including recipes for: Kung Pao Chicken, Country-Style BBQ Spareribs, and Beef and Mushrooms.

One Pan, One Pot including recipes for: One-Dish Baked Fajitas, Sunrise Skillet, and Mushroom Asparagus Chicken Stir Fry.

Casseroles including recipes for: Cheesy Chicken Quinoa Casserole, Country Breakfast Casserole, and John Wayne Casserole.

We are so excited to share these recipes with you. Order your copy today!

DINNER MADE EASY with Six Sisters’ Stuff <—– Click here to order!

How to make John Wayne casserole make with Bisquick:

Begin by preheating the oven to 325 degrees and spraying down your 9×13 baking dish with nonstick cooking spray. 

Then, using your medium-sized pan, brown the ground beef and then add in the taco seasoning and ¾ cup of water to the pan and let it simmer for 3-4 minutes until it begins to thicken up. 

Then, in your medium mixing bowl, stir together the sour cream, mayo, half of the cheese, and half of the onion and set it aside once it’s all combined. 

In another small mixing bowl, mix together the Bisquick biscuit mix and water to make the biscuit dough. Then, in the greased pan, press the dough into the bottom and about a ½ inch up the sides. 

Now, in another pan saute the other half of the onions and green peppers until they are just slightly tender. 

Then top the biscuits in this order:

  1. Cooked ground beef
  2. Diced tomatoes
  3. Sauteed green peppers and onions
  4. Can of green chilies
  5. Sour cream and cheese mixture
  6. Remaining cheese on top

Be sure to follow those layers for the best success! Then pop the family dinner recipe in the oven for 30-35 minutes or until the edges begin to brown slightly. 



Wonderful recipes for families on the go!

I know a lot of you have families that you are preparing dinner for and the weeknights can get hectic with everyone’s schedule with sports and other extracurricular activities.

If that is you, you need to have a look at our Youtube channel and all of the fast and easy recipes we make from start to finish!

We even have a video where we show you 4 wonderfully easy dump and go Instant Pot recipes that you can throw together on those busy nights! 


More man casserole recipes even the pickiest man will love!

Serves: 8

John Wayne Casserole (Beef and Biscuit Casserole)

John Wayne casserole (beef and biscuits casserole), is one of a kind with its taco ingredients and biscuit mix. You do NOT want to pass this up.

20 minPrep Time

30 minCook Time

50 minTotal Time

Save RecipeSave Recipe


  • 2 pounds ground beef
  • 1 (1 ounce) package taco seasoning mix
  • 3/4 cup water
  • 1/2 cup sour cream
  • 1/2 cup light mayonnaise
  • 1 cup shredded cheddar cheese (divided)
  • 1 onion (diced and divided)
  • 2 cups Bisquick biscuit mix
  • 1 cup water
  • 1 green bell pepper (diced)
  • 2 Roma tomatoes (diced)
  • 1 (4 ounce) can green chilies


  1. Preheat oven to 325 degrees. Spray a 9 x 13 inch baking dish with non-stick cooking spray.
  2. Brown ground beef until no longer pink, drain grease. Then add taco seasoning and water and let simmer for 3-4 minutes.
  3. In a medium bowl mix sour cream, mayo, half of the cheese, and half of the onion together and set aside.
  4. In another bowl, mix together biscuit mix and water to make a soft dough. Press dough into the bottom and 1/2" up the sides of greased 9 x 13 inch pan.
  5. Saute remaining onions and green peppers until barely tender.
  6. On top of the biscuit, layer the remaining ingredients in this order: ground beef, diced tomatoes, green peppers and onions, green chilies, sour cream mixture, and remaining cheddar cheese.
  7. Bake for 30-35 minutes or until edges are slightly browned.


Main Course
seafood free
treenut free
sesame free
mustard free



4966 cal


327 g


286 g


215 g
Click Here For Full Nutrition, Exchanges, and My Plate Info

Be sure to not miss another recipe! 

Follow Six Sisters’ Stuff on Instagram | Facebook | Pinterest | YouTube


If you made our recipe be sure to tag us on Instagram so we can see your hard work using #sixsistersstuff.

Print Friendly, PDF & Email

Comment on this Recipe

74 Responses to “John Wayne Casserole (Beef and Biscuit Casserole)”

  1. Katharine
    I'm excited to try this recipe. I LOVE John Wayne. Two of his movies I really love are Angel and the Badman and Hondo, but there are soooo many more. I think I'll put on a John Wayne movie while eating the casserole. :)
  2. Pam Stafford
    My husband and children do not like peppers or green chilies so if I left this out would it change the taste a whole lot? Just wondering, sadly, I have a very picky family, some likes tomatoes, some don't, some like onions, some don't. I think you get the picture and it is so hard to cook for my bunch sometimes! :0(
  3. Christi Dott
    Okay, I have become so addicted to your recipes!! I have just made this, just stuck it in the oven... and again tweaked for gluten free. I used the GF Bisquick. It does have more ingredients than regular Bisquick for biscuits, so I added those as well and will keep my fingers crossed!! So far all of my GF tweaks on your recipes have worked out so I am thinking this one will as well!!
  4. I made this recipe last night and it was amazing! I didn't sauté the green peppers or the onions but still tasted just as good. I was worried that the biscuit mix was going to be a little doughy but it turned out great and the fam loved it! Thank you for the great recipe! Two thumbs up :)
  5. melanie
    I just found this site and the name of recipe got my attention. I 'll admit I am a bit suspect of someone who doesn't know the Duke but will try recipe for supper tonight. I 'm sure will go over very well simply due to the name, LOL. Be back with results tomorrow.
  6. FANTASTIC! I made it tonight and even Mr. FussPot loved it....and he doesn't like anything. It smelled so good cooking. I did add a little more Bisquick to the dough because it was quite runny. It came out perfect...cut in beautiful squares. Thank you for a wonderful recipe.
    • Hi Ruth, We have not made it the night before and cooked it the next day. But reading over it carefully I think it would work just fine. The dough goes on the bottom, so be sure that it comes up the side of the dish and is sealed well so that the other ingredients don't ooze down over the sides. That may cause it to be soggy dough. Let us know how it all turns out. It should work!! :)
  7. Made this tonight and it was delicious! Used a can of tomatoes with chiles (drained) instead of fresh tomatoes since that's all I had. Also left out the onions and bell pepper. My picky kids (11 and 15-year old daughters) both loved it, so that says a lot!
  8. Made this tonight with a couple changes. I used breakfast sausage instead of ground beef and cooked the bell peppers and onions with the meat. Since the sausage is spicy enough I omitted the green chiles. Great dinner that everyone really enjoyed, thank you for sharing this recipe! YUM YUM YUM!
  9. I almost never comment on pintrest recipes but felt that I had to add a note. We made this tonight and it was completely forgettable. Almost no flavor. The biscuit layer was bland. The meat was bland and all of the veggies should have been cooked before being added to any layer. To be clear. I added more taco seasoning and Sriracha to the meat and garlic to the pepper and onion mix and we still felt we could have take a pass. Better luck next time.
  10. I like the heartiness of this dish but I agree with Susan, this was very very bland. I added extra taco seasoning, seasoned salt and garlic to the ground beef, but my fiancé still said it had no flavor and had to add hot sauce to it. It may have more flavor if salsa was used in place of the tomatoes, or maybe even some Rotel. If I do make this again, major adjustments will be made.
  11. katherine
    I liked it. I combined the peppers and onions with the ground beef when I put the taco seasoning in it. I put 2 packages of taco seasoning instead of one (1 packet per pound of ground beef is usual). I skipped the mayo and used 1 c sour cream. I used a can of diced tomatoes instead of fresh. Since several people are from outside of the country, here's a note on what Bisquick contains: Self rising flour consists of flour, salt, and baking powder. Bisquick contains all of these ingredients plus hydrogenated vegetable shortening. One cup of Bisquick can be substituted by a mixture of one cup of flour, 1½ teaspoons of baking powder, ½ teaspoon of salt, and 1 tablespoon of oil or melted butter. And if you have self rising flour just add oil and you are good.
  12. Looking for a new casserole idea I came upon this recipe that sounded interesting. After reading the reviews I decided to make a few changes. I added a can of black beans drained I can of corn drained cooked the green peppers and onions with the meat once it was done in season that with adobo. Had about a teaspoon of Worcestershire sauce to the meat mixture as well as additional half a packet of taco seasoning Mary had I also added a layer of sorrow and cream and onion mashed potatoes on top of the mayonnaise and sour cream mixture then top that with cheddar cheese cooked it and then broiled it at the end. Delicious! Reminded me of a Mexican style shepherds pie
  13. You stated you did not know where the name of the recipe came from. This is a quote from the "12 Tomatoes" website. John Wayne was asked to contribute a recipe for the cookbook, "Cooking with Love from Cara and Her Friends". Proceeds from the book were to benefit the American Cancer Society. The book was a compilation of recipes from celebrities and John Wayne submitted his favorite casserole. This recipe was released in the book in 1979, the same year that Wayne died from cancer.
  14. Also, this website gives a very tender story about the Cookbook. It was written and the recipes compiled by a 10 year old that wanted to do something to raise money for the American Cancer Society. John Wayne was only one of many celebrities that submitted a favorite recipe for Cara's book.

Leave a Reply to Anne

Click here to cancel reply.