John Wayne Casserole (Beef and Biscuit Casserole)Recipe

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Published: July 10, 2021Updated: October 21, 2021Author: Camille Beckstrand
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Okay, raise your hand if you LOVE casseroles! My hand is definitely up, I love casseroles. John Wayne casserole (beef and biscuits casserole), is one of a kind with its taco ingredients and biscuit mix. You do NOT want to pass this up.
John Wayne Casserole (Beef and Biscuit Casserole)Recipe

Honestly, I am not quite sure how this recipe got its name, but I think it’s because John Wayne loved casseroles too!

I know some people aren’t a huge fan of casseroles, but as a mom, I absolutely love them. It’s so nice to be able to throw something together and walk away and get more done while it’s cooking. 

Also, it doesn’t hurt that my kids eat this WITHOUT COMPLAINING! It is a hit in our house. I’ve even considered doubling the batch so I actually get to have some leftovers. That’s another reason casseroles are one of my favorite things to make, who doesn’t love leftovers?

Want to check out some more awesome casserole recipes? Take a look at our homemade green bean casserole without condensed soup, chicken enchilada casserole, and of course our super popular million dollar casserole! Do yourself a favor and bookmark these because you will be making them over and over again!

John Wayne Casserole in White Casserole dish

UPDATE YOUR SHOPPING LIST WITH THESE INGREDIENTS!

JOHN WAYNE CASSEROLE INGREDIENTS:

  1. Ground beef
  2. Taco seasoning mix package
  3. Water
  4. Sour cream
  5. Light mayonnaise
  6. Shredded cheddar cheese
  7. Onion
  8. Bisquick biscuit mix
  9. Green bell pepper
  10. Roma tomatoes
  11. Can of green chilies
Ingredients for John Wayne Casserole

If you make a lot of taco recipes you might even consider making your own (maybe even in bulk!) using this taco seasoning recipe from Allrecipes.com. 

Another great recipe to have on hand is this homemade bisquick recipe! You can make your own and save a trip to the store!

If you don’t have light mayonnaise, you can use regular mayonnaise. Miracle whip could also be substituted, but it will give the casserole a little bit different taste.

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Other items you’ll need for this beef and biscuit casserole:

  • 9×13 inch baking dish (check THIS one out)
  • Nonstick cooking spray
  • Small mixing bowl
  • Medium mixing bowl
  • Medium-sized pan (similar to THIS) 

Related Article: Our Korean Beef and Rice is a must if you’re dealing with picky eaters! 

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How to make John Wayne casserole with Bisquick:

Begin by preheating the oven to 325 degrees and spraying down your 9×13 baking dish with nonstick cooking spray. 

Skillet with ground beef and taco seasoning

Then, using your medium-sized pan, brown the ground beef and then add in the taco seasoning and ¾ cup of water to the pan and let it simmer for 3-4 minutes until it begins to thicken up. 

Mixing bowl with sour cream , cheese and onions

Then, in your medium mixing bowl, stir together the sour cream, mayo, half of the cheese, and half of the onion and set it aside once it’s all combined. 

In another small mixing bowl, mix together the Bisquick biscuit mix and water to make the biscuit dough. Then, in the greased pan, press the dough into the bottom and about a ½ inch up the sides. 

Now, in another pan saute the other half of the onions and green peppers until they are just slightly tender. 

Then top the biscuits in this order:

  1. Cooked ground beef
  2. Diced tomatoes
  3. Sauteed green peppers and onions
  4. Can of green chilies
  5. Sour cream and cheese mixture
  6. Remaining cheese on top
Layering stages for the John Wayne Casserole in a white casserole dish

Be sure to follow those layers for the best success! Then pop the family dinner recipe in the oven for 30-35 minutes or until the edges begin to brown slightly. 

IF YOU LOVE THIS EASY RECIPE, TRY OUR EASY BISCUIT CHICKEN POT PIE!  WITH JUST A FEW SIMPLE INGREDIENTS, YOU’LL HAVE A DELICIOUS DINNER READY IN NO TIME!

Wonderful recipes for families on the go!

I know a lot of you have families that you are preparing dinner for and the weeknights can get hectic with everyone’s schedule with sports and other extracurricular activities.

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We even have a video where we show you 4 wonderfully easy dump and go Instant Pot recipes that you can throw together on those busy nights! 

More man casserole recipes even the pickiest man will love!

Serves: 8

John Wayne Casserole (Beef and Biscuit Casserole) Recipe

John Wayne casserole (beef and biscuits casserole), is one of a kind with its taco ingredients and biscuit mix. You do NOT want to pass this up.
Prep Time 20 mins
Cook Time 30 mins
Total Time 50 mins
Print Pin

Ingredients

  • 2 pounds ground beef
  • 1 ounce taco seasoning mix 1 package
  • ¾ cup water
  • ½ cup sour cream
  • ½ cup light mayonnaise
  • 1 cup shredded cheddar cheese divided
  • 1 onion diced and divided
  • 2 cups Bisquick biscuit mix
  • 1 cup water
  • 1 green bell pepper diced
  • 2 roma tomatoes diced
  • 4 ounces diced green chilies 1 can

Instructions

  • Preheat oven to 325 degrees. Spray a 9 x 13 inch baking dish with non-stick cooking spray.
  • Brown ground beef until no longer pink, drain grease. Then add taco seasoning and water and let simmer for 3-4 minutes.
  • In a medium bowl mix sour cream, mayo, half of the cheese, and half of the onion together and set aside.
  • In another bowl, mix together biscuit mix and water to make a soft dough. Press dough into the bottom and 1/2" up the sides of greased 9 x 13 inch pan.
  • Saute remaining onions and green peppers until barely tender.
  • On top of the biscuit, layer the remaining ingredients in this order: ground beef, diced tomatoes, green peppers and onions, green chilies, sour cream mixture, and remaining cheddar cheese.
  • Bake for 30-35 minutes or until edges are slightly browned.

Notes

  • Try gluten free Bisquick to make this recipe Gluten Free Friendly

Nutrition

Calories: 422 kcal · Carbohydrates: 26 g · Protein: 31 g · Fat: 21 g · Saturated Fat: 9 g · Polyunsaturated Fat: 3 g · Monounsaturated Fat: 8 g · Trans Fat: 1 g · Cholesterol: 95 mg · Sodium: 953 mg · Potassium: 589 mg · Fiber: 2 g · Sugar: 7 g · Vitamin A: 776 IU · Vitamin C: 18 mg · Calcium: 195 mg · Iron: 4 mg

Equipment

  • 9×13-inch Baking Pan
  • Non-stick Cooking Spray
  • Medium Mixing Bowl (2)
  • Sauté pan

Recipe Details

Course: Main Course
Cuisine: American

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John Wayne Casserole (Beef and Biscuit Casserole)

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  1. pam says:
    June 23, 2014
    Our family tried this recipe about a year ago and we liked it,
    Reply
  2. Tom says:
    June 23, 2014
    This post is suspect. How can you name it John Wayne and include "light" mayo? :) Just kidding. I'll give it a try when I feel adventurous. Go see an old John Wayne movie. He has some classics.
    Reply
    • William Macklin says:
      July 31, 2014
      Perhaps if The Duke has eaten more light foods he would still be alive. Or did he die from aids? I made it, served it, ate it and passed it along to all my friends - both of them. What a great recipe. John (The Duke) Wayne may have been the most prolific actor to ever hit Hollywood. He starred in movies with just about everybody who was anybody, including Rick(ie) Nelson in Rio Bravo. The first movie I saw him in was "She Wore A Yellow Ribbon". It was 1947 or 48 and cost 5 cents to see it in Republican City Nebraska. Popcorn was 2 cents as were Jujubees. What do they cost at the theatre today?
      Reply
      • Kelly says:
        October 3, 2015
        I love the Duke!
        Reply
        • patricia rhorer says:
          January 20, 2018
          Me too John Wayne go many years back and lots of good memories watching his movies with my dad
          Reply
      • Lesley says:
        September 27, 2016
        His death was the direct result of smoking up to 10 packs of cigarettes a day...disgusting! And sad that help quitting was not pushed in his lifetime.
        Reply
        • Rita says:
          October 24, 2018
          He did not smoke 10 packs a day. Are you crazy ?
          Reply
        • John Rourke says:
          January 17, 2019
          I'm not sure (10 packs a day?) where you get your facts, but I have never read/seen where he smoked that much.. Back in that day, it appeared everyone smoked too much in the movies. IMPOSSIBLE
          Reply
      • theresa says:
        November 1, 2016
        he passed from cancer
        Reply
      • L.S. Jones says:
        March 4, 2018
        John Wayne died from complications from years of smoking (lung cancer) like most of the old classic Hollywood be actors. They didn't know then what we know now. At least not till it was too late. Very little of his overall life was he over weight. He was just a big man.
        Reply
        • Karen says:
          November 30, 2018
          He, Susan Hayward along with the crew of filming of “Gengis Kahn”(?spelling) died from cancers. The filming site was in Nevada desert where early nuclear tests were done. At the time of filming took place no one knew of there was lingering danger. Wayne’s two older son’s, Mike and Patrick, that were at the filming site also battled cancer,
          Reply
          • bruce meyers says:
            June 26, 2019
            this I believe
      • Sandy Quinn says:
        February 27, 2019
        He died from lung cancer, not aids
        Reply
    • Ami says:
      February 1, 2017
      In the South we use Dukes mayonnaise...how appropriate?!?!
      Reply
      • Gail says:
        January 14, 2020
        absolutely, Dukes mayonnaise is the best :)
        Reply
  3. Crystal says:
    June 23, 2014
    What happened to the print button that allowed generated pdfs of the recipes? I liked saving the paper and space on my shelf.
    Reply
    • Cyd says:
      June 23, 2014
      The Print button is in the right hand top corner in the blue box where the ingredients and recipe are listed. Hope this helps!
      Reply
    • Imo says:
      August 20, 2020
      I loved all John Wayne’s movies! Here in Texas we pretty much grew up with seeing him on the silver screen. I knew he smoked but I think a person can drive that weight and lite foods in the ground! My Grandma ate fried bologna (mainly because that’s all they could afford) fried chicken and used lard to fry everything. She lived to be well in her 90’s. Got my casserole in the oven now and can’t wait to try it with a side salad.
      Reply
  4. Joan in VA says:
    June 24, 2014
    You've NEVER heard of John Wayne?????????? I knew you were young, but his movies are all over cable TV. Quotes from him and pictures are all over the internet. Sigh ... I'm too old.
    Reply
  5. Michelle says:
    June 28, 2014
    Couldn't you saute the onion and green pepper with the ground beef and save a step? All going in the same pan so just wondering!
    Reply
    • Cyd says:
      June 30, 2014
      Sure, that will work great too!
      Reply
  6. Anne says:
    June 30, 2014
    Trying It tonight! As we speak it Is in the oven! Thank you! Yay!
    Reply
    • Chelsea says:
      May 26, 2019
      Is there a way to alter the recipe for just 1 pound of ground beef? It's just my fiance and I and I hate to waste!
      Reply
      • Tara Hendrickson says:
        February 23, 2020
        I made mine in 2 separate foil pans just for this reason! However wondering if this can be frozen before I bake it?
        Reply
  7. Debbie C says:
    July 1, 2014
    Does the bottom crust get good and done?
    Reply
    • Steph says:
      July 2, 2014
      Yes! It's not a super wet dough, so it comes out nice and done! Enjoy!
      Reply
      • Tish says:
        July 19, 2014
        I tried and that was not my experience with the bisquick dough. Recipe calls for 2 cups and 1 cup water, and it was super runny.
        Reply
        • Dawn Leadbetter says:
          July 26, 2014
          I just added about 1/2 to 3/4 cup more bisquick. Came out perfect.
          Reply
  8. Katharine says:
    July 2, 2014
    I'm excited to try this recipe. I LOVE John Wayne. Two of his movies I really love are Angel and the Badman and Hondo, but there are soooo many more. I think I'll put on a John Wayne movie while eating the casserole. :)
    Reply
    • Steph says:
      July 2, 2014
      Hahahaha I think that is an EXCELLENT idea!
      Reply
  9. Pam Stafford says:
    July 4, 2014
    My husband and children do not like peppers or green chilies so if I left this out would it change the taste a whole lot? Just wondering, sadly, I have a very picky family, some likes tomatoes, some don't, some like onions, some don't. I think you get the picture and it is so hard to cook for my bunch sometimes! :0(
    Reply
    • Cyd says:
      July 8, 2014
      I totally understand Pam! You could easily leave out the peppers and green chiles, but the taste would be blander. (is that a word?) But it sounds like they probably want it that way. Let us know how it all turns out! Thanks so much for dropping by our blog! Have a great day! Cyd (mom of the Six Sisters)
      Reply
      • John Rourke says:
        January 17, 2019
        I believe the correct grammar would be: "more bland"
        Reply
  10. Christi Dott says:
    July 7, 2014
    Okay, I have become so addicted to your recipes!! I have just made this, just stuck it in the oven... and again tweaked for gluten free. I used the GF Bisquick. It does have more ingredients than regular Bisquick for biscuits, so I added those as well and will keep my fingers crossed!! So far all of my GF tweaks on your recipes have worked out so I am thinking this one will as well!!
    Reply
  11. Debi says:
    July 21, 2014
    I love this recipe. I have a brother with celiac disease, so it works well with the gluten-free Bisquick. I use drained petite diced tomatoes, did not like the tomato skin in the casserole.
    Reply
  12. KP says:
    July 22, 2014
    I made this recipe last night and it was amazing! I didn't sauté the green peppers or the onions but still tasted just as good. I was worried that the biscuit mix was going to be a little doughy but it turned out great and the fam loved it! Thank you for the great recipe! Two thumbs up :)
    Reply
  13. melanie says:
    July 22, 2014
    I just found this site and the name of recipe got my attention. I 'll admit I am a bit suspect of someone who doesn't know the Duke but will try recipe for supper tonight. I 'm sure will go over very well simply due to the name, LOL. Be back with results tomorrow.
    Reply
  14. Sherry says:
    September 2, 2014
    Going to try this dinner tonight!!Hope all enjoys it...
    Reply
  15. Jamie says:
    September 10, 2014
    Very tasty! I skipped making the biscuit dough and just bought the pillsbury home style can of biscuits. I used about one and a half cans. Came out perfect!
    Reply
  16. sheryl says:
    September 12, 2014
    You must not be from America if you don't know who John Wayne is! Shame on you. Also, John died from cancer because he made all of his movies in the same areas where they did all of the bomb testings.
    Reply
    • Nancy says:
      February 13, 2018
      Thank you, for mentioning the movie. John Wayne was a smoker; but the movie that he made on the site where bombs were tested; also, killed several other people who stared in that movie.
      Reply
  17. Skyye says:
    September 17, 2014
    Hey all. Just wondering if anyone out there knows what would be the Australian equivalent to Bisquik, please????
    Reply
    • Tracey says:
      September 18, 2014
      Hi Skyye - you could just mix up a basic scone dough, or use Lions Classic Scone Mix.
      Reply
    • Louise says:
      October 17, 2014
      I used a regular biscuit recipe. And also threw in a can of black beans. This was a big hit with the family, and I'll definitely do it again.
      Reply
  18. Nuala says:
    September 19, 2014
    With cooler weather around this area, I'd definitely make this "comfort food" recipe. I'll use the real mayonnaise though, for I intend to sail "In Harm's Way"...
    Reply
  19. Jen says:
    September 22, 2014
    So, I was just wondering if you could use biscuits that are already made and just not cook it as long?!
    Reply
  20. Donna says:
    September 22, 2014
    FANTASTIC! I made it tonight and even Mr. FussPot loved it....and he doesn't like anything. It smelled so good cooking. I did add a little more Bisquick to the dough because it was quite runny. It came out perfect...cut in beautiful squares. Thank you for a wonderful recipe.
    Reply
  21. Ruth says:
    September 26, 2014
    Can I prep this all in the casserole dish the night before and then just cook it the next day? Will it mess up the recipe?
    Reply
    • Cyd says:
      September 29, 2014
      Hi Ruth, We have not made it the night before and cooked it the next day. But reading over it carefully I think it would work just fine. The dough goes on the bottom, so be sure that it comes up the side of the dish and is sealed well so that the other ingredients don't ooze down over the sides. That may cause it to be soggy dough. Let us know how it all turns out. It should work!! :)
      Reply
  22. Shannon says:
    September 29, 2014
    This was a pretty quick and eaay recipe. My whole family liked it!!!
    Reply
  23. Michelle says:
    November 10, 2014
    Made this tonight and it was delicious! Used a can of tomatoes with chiles (drained) instead of fresh tomatoes since that's all I had. Also left out the onions and bell pepper. My picky kids (11 and 15-year old daughters) both loved it, so that says a lot!
    Reply
  24. Kristy Sebring says:
    July 5, 2015
    will have to try using the bisquick gluten free mix.
    Reply
  25. Carol says:
    July 5, 2015
    Am I the only one thinking this would be sooo good with a cornbread base?
    Reply
  26. Jeffrey says:
    July 21, 2015
    I added corn and black beans for a little more variety.
    Reply
  27. Andria says:
    October 5, 2015
    Made this tonight with a couple changes. I used breakfast sausage instead of ground beef and cooked the bell peppers and onions with the meat. Since the sausage is spicy enough I omitted the green chiles. Great dinner that everyone really enjoyed, thank you for sharing this recipe! YUM YUM YUM!
    Reply
  28. Joyce says:
    October 21, 2015
    couldn't stand Wayne when he was alive, sure don't think about him now that he's dead. The casserole, on the other hand, appears to be noteworthy, unlike the late actor.
    Reply
  29. susan says:
    December 20, 2015
    I almost never comment on pintrest recipes but felt that I had to add a note. We made this tonight and it was completely forgettable. Almost no flavor. The biscuit layer was bland. The meat was bland and all of the veggies should have been cooked before being added to any layer. To be clear. I added more taco seasoning and Sriracha to the meat and garlic to the pepper and onion mix and we still felt we could have take a pass. Better luck next time.
    Reply
  30. Ciara says:
    February 11, 2016
    I like the heartiness of this dish but I agree with Susan, this was very very bland. I added extra taco seasoning, seasoned salt and garlic to the ground beef, but my fiancé still said it had no flavor and had to add hot sauce to it. It may have more flavor if salsa was used in place of the tomatoes, or maybe even some Rotel. If I do make this again, major adjustments will be made.
    Reply
  31. Cindy says:
    April 2, 2016
    I can't wait to try it. After reading some of the comments , I plan to change it up a little bit. I am going to add medium salsa and retried beans. It sounds fabulous.
    Reply
  32. Morgan says:
    April 3, 2016
    I don't know what I did wrong, but this did not turn out good. It tasted like two completely opposite recipes combined together, and the resulting flavor was just, conflict.
    Reply
  33. Jessica says:
    April 16, 2016
    This wasn't a difficult recipe but many steps. It was ok but not something I'd make again.
    Reply
  34. katherine says:
    May 26, 2016
    I liked it. I combined the peppers and onions with the ground beef when I put the taco seasoning in it. I put 2 packages of taco seasoning instead of one (1 packet per pound of ground beef is usual). I skipped the mayo and used 1 c sour cream. I used a can of diced tomatoes instead of fresh. Since several people are from outside of the country, here's a note on what Bisquick contains: Self rising flour consists of flour, salt, and baking powder. Bisquick contains all of these ingredients plus hydrogenated vegetable shortening. One cup of Bisquick can be substituted by a mixture of one cup of flour, 1½ teaspoons of baking powder, ½ teaspoon of salt, and 1 tablespoon of oil or melted butter. And if you have self rising flour just add oil and you are good.
    Reply
  35. Pamela says:
    September 18, 2016
    Very hearty recipe. I did add a can of black beans and a few red pepper flakes. Will definitely make again.
    Reply
  36. Tami says:
    November 15, 2016
    Looking for a new casserole idea I came upon this recipe that sounded interesting. After reading the reviews I decided to make a few changes. I added a can of black beans drained I can of corn drained cooked the green peppers and onions with the meat once it was done in season that with adobo. Had about a teaspoon of Worcestershire sauce to the meat mixture as well as additional half a packet of taco seasoning Mary had I also added a layer of sorrow and cream and onion mashed potatoes on top of the mayonnaise and sour cream mixture then top that with cheddar cheese cooked it and then broiled it at the end. Delicious! Reminded me of a Mexican style shepherds pie
    Reply
  37. Annie Savidge says:
    November 27, 2016
    This would be good with a "pizza" slant, too. You could put some pizza sauce down before or after ground beef or mix it into the beef, and then trade out the peppers and stuff for olives, mushrooms and other things you like on your pizza.
    Reply
  38. Shelbie says:
    December 4, 2016
    Is this something that you can freeze?
    Reply
    • Camille (Six Sisters Stuff) says:
      December 6, 2016
      Hi Shelbie! I have never tried freezing it . . . I worry that the biscuit part might get a little soggy when you thaw it. If you try it, let us know!
      Reply
  39. Amy Smith says:
    February 2, 2017
    What can I substitute for the Mayo and tomatos. If I use the tomatos, can you use the rotel cans with diced tomatos and peppers?
    Reply
  40. Sharon Williamson says:
    January 12, 2020
    I am not a fan of bisquick but think this would be great with cornbread on it!
    Reply
  41. Linda says:
    January 17, 2020
    I see the ingredients, but WHERE are the directions?????
    Reply
    • Cyd says:
      January 29, 2020
      Hi Linda. I just went to the post and it's all there. The ingredients and right underneath is the directions for the recipe.
      Reply
  42. Peg Weigle says:
    March 17, 2020
    I could not find the amounts for this recipe so improvised. It better be good. When I finally scrolled down to make this comment, I found it. Way too much junk on this site to find the actual recipe!!!
    Reply
    • Cyd says:
      March 18, 2020
      The full recipe including ingredients and directions is all there! Have a terrific day!
      Reply
  43. Ed says:
    July 11, 2020
    You stated you did not know where the name of the recipe came from. This is a quote from the "12 Tomatoes" website. John Wayne was asked to contribute a recipe for the cookbook, "Cooking with Love from Cara and Her Friends". Proceeds from the book were to benefit the American Cancer Society. The book was a compilation of recipes from celebrities and John Wayne submitted his favorite casserole. This recipe was released in the book in 1979, the same year that Wayne died from cancer.
    Reply
  44. Ed says:
    July 11, 2020
    Also, this website gives a very tender story about the Cookbook. It was written and the recipes compiled by a 10 year old that wanted to do something to raise money for the American Cancer Society. John Wayne was only one of many celebrities that submitted a favorite recipe for Cara's book. https://deansfarmmarket.com/john-wayne-casserole-story/
    Reply
  45. Deb says:
    September 14, 2020
    2 cups of bisquik and 1 cup of water wrong. Soupy not doughy
    Reply
  46. Jayze says:
    October 10, 2020
    I made this for my husband and son, the loved it! I used the tubed pizza dough for the crust. It was faster and easier. I also used 2 cups of cheese. It's a keeper for sure.
    Reply
  47. Liz Cooper says:
    March 5, 2021
    Tasted really good but was dry.
    Reply
  48. EMarie says:
    April 8, 2021
    I want to try this recipe!! My question is can it be put together and refrigerated, then baked next morning? And would there be any change in the baking time?
    Reply
    • Momma Cyd says:
      April 8, 2021
      You can totally make this recipe the night before and bake the next day. The cook time may be just a bit longer where it has been sitting in the fridge all night. But cook until heated through and the edges are slightly browned.
      Reply
  49. Ginny says:
    May 18, 2021
    We have made this recipe for a long time and really love it. It is adjustable and i can make gluten free when family comes over. Another dish of it is in the oven now.
    Reply
    • Momma Cyd says:
      May 18, 2021
      So glad to hear that you like this recipe. It's one of our favorites too!
      Reply
  50. SDuhe says:
    August 3, 2021
    How do you prepare John Wayne Casserole to be frozen? Thank you
    Reply
  51. Matt says:
    August 25, 2021
    So, I honestly don't remember what I searched for, but this page/recipe was one of the top hits. It seemed simple and quick enough (I came across it at 6pm on a weekday) and none of the ingredients rubbed me wrong so I made it - although I have to say the idea of mayo and sour cream kinda scared me a bit. Turns out, it's fantastic. I mean, I like it better with a bit of hot sauce on it, but really, it's great as is. The only change I made was using garden tomatoes instead of Roma - not 100% sure which plant they came from but probably Early Girl. Oh, and regular mayo. Suffice to say, I think I'll keep this in the rotation.
    Reply
  52. Janet Bradley says:
    October 9, 2021
    This sounds amazing, just one question, could I use salsa instead of diced tomatoes?
    Reply
    • Momma Cyd says:
      October 12, 2021
      Yes, that would work fine.
      Reply
  53. N. J. York says:
    November 23, 2021
    Tried this today it's very good. I left out green pepper due to the fact they are too expensive in Alaska.
    Reply
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