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4.93 from 26 votes

Chicken Zucchini Casserole Recipe

This delicious comfort food is made with chicken and zucchini tossed in a cream sauce and topped with stuffing and cooked to perfection.
Prep Time10 mins
Cook Time45 mins
Total Time55 mins
Course: Main Course
Cuisine: American
Keyword: Best Casserole Recipe, Casserole, Chicken, Zucchini
Servings: 8
Calories: 268kcal
Author: Kristen Hills


  • 9x13-inch Baking Pan
  • Large Mixing Bowl
  • Rubber spatula


  • 6 ounces boxed stuffing mix (such as Stove Top)
  • ½ cup butter melted
  • 4 diced zucchini (about 4-5 cups)
  • 3 boneless, skinless chicken breasts cooked and diced
  • 10 ½ ounces canned cream of chicken soup
  • ½ onion diced
  • ½ cup sour cream


  • Preheat oven to 350 degrees F.
  • In a large bowl, combine the stuffing mix and melted butter. Set aside 1/2 cup of the mixture for topping.
  • Add zucchini, cooked chicken, cream of chicken soup, onion and sour cream to the stuffing in the large bowl.
  • Spread zucchini mixture in an even layer in a 9 x 13 inch glass pan sprayed with nonstick cooking spray.
  • Sprinkle reserved stuffing mix on top and bake, uncovered, for 40-50 minutes or until cooked through and the top is golden brown.



  • Try using a rotisserie chicken from the deli for this recipe to save time and add a savory flavor.


Calories: 268kcal | Carbohydrates: 11g | Protein: 12g | Fat: 20g | Saturated Fat: 10g | Trans Fat: 1g | Cholesterol: 68mg | Sodium: 533mg | Potassium: 480mg | Fiber: 2g | Sugar: 4g | Vitamin A: 787IU | Vitamin C: 19mg | Calcium: 51mg | Iron: 1mg