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The Best Cheeseburger Casserole Recipe

All the goodness of a cheeseburger, but in a casserole. Whole wheat pasta, tossed in a seasoned tomato sauce with meat and cheese, then topped with shredded lettuce and tomatoes.
Prep Time20 mins
Cook Time25 mins
Total Time45 mins
Course: Main Course
Cuisine: American
Keyword: Best Casserole Recipe, Casserole, cheeseburger casserole, Ground beef casserole recipe
Servings: 6
Calories: 379kcal


  • large pot
  • Large Skillet
  • 9x13 Inch Baking Dish


  • 8 ounces whole wheat penne pasta
  • 2 teaspoons olive oil
  • 1 pound ground turkey
  • ½ cup diced onion
  • 1 teaspoon minced garlic
  • 1 teaspoon steak seasoning
  • 29 ounces diced tomatoes 2 (14.5oz cans), do not drain
  • 2 Tablespoons tomato paste
  • 1 Tablespoon mustard
  • 1 Tablespoon pickle relish
  • 1 cup shredded cheddar cheese divided
  • ½ cup sour cream
  • 1 tomato diced
  • ½ cup shredded lettuce


  • Preheat oven to 350 degrees F.
  • Bring a large pot of water to a boil, add pasta and cook according to package directions for al dente; drain and set aside.
  • In a large skillet or pan, heat olive oil over medium-high heat.
  • Add ground turkey, diced onion, minced garlic and steak seasoning to the pan and cook until turkey is browned; drain any excess liquid.
  • Add undrained cans of diced tomatoes, tomato paste, mustard, pickle relish, 1/2 cup cheddar cheese and sour cream.
  • Reduce heat to medium and stir continuously until it starts bubbling.
  • Add mixture to cooked Penne pasta and mix until well combined.
  • Pour mixture into a 9 x 13 inch baking dish sprayed with nonstick cooking spray.
  • Top with remaining 1/2 cup cheese.
  • Bake for 20-25 minutes or until cheese is melted and casserole is completely heated through.
  • Top with shredded lettuce and diced tomatoes before serving.


To make this a Freezer Meal:

  •  Follow the recipe directions until it comes time to cook the casserole.
  • Rather than cooking the casserole, cover your pan tightly with aluminum foil then wrap tightly with plastic wrap.  Place in the freezer in a level spot.
  • If you have frozen your casserole and need to reheat it, simply place the frozen casserole in the fridge 24 hours before intended use.  After your casserole has thawed completely, cook following recipe directions.


Calories: 379kcal | Carbohydrates: 34g | Protein: 29g | Fat: 14g | Saturated Fat: 7g | Trans Fat: 1g | Cholesterol: 71mg | Sodium: 285mg | Potassium: 666mg | Fiber: 5g | Sugar: 7g | Vitamin A: 785IU | Vitamin C: 18mg | Calcium: 216mg | Iron: 3mg