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5 from 1 vote

Pizza Pasta Casserole Recipe

All your favorite pizza toppings mixed together with pasta make this Pizza Pasta Casserole a family favorite!
Prep Time10 mins
Cook Time40 mins
Total Time50 mins
Course: Main Course
Cuisine: American
Keyword: Best Casserole Recipe, easy casserole, pasta casserole, pizza casserole
Servings: 8
Calories: 389kcal


  • Large Skillet
  • 9x13-inch Baking Pan
  • Non-stick Cooking Spray


  • 3 cups penne pasta (I used protein pasta, whole wheat works great too)
  • teaspoons olive oil
  • 1 onion diced
  • 1 green bell pepper diced
  • cups sliced fresh mushrooms
  • 4 garlic cloves minced
  • 8 ounces Turkey Italian Sausage (casings removed - hot Italian sausage works too)
  • 1 cup turkey pepperonis (cut into quarters)
  • 28 ounces diced tomatoes 1 can, drained
  • 15 ounces tomato sauce 1 can
  • ½ Tablespoon balsamic vinegar
  • ½ Tablespoon Italian seasoning
  • salt and pepper, to taste
  • cups shredded Mozzarella cheese


  • Preheat oven to 350 degrees. Prepare the pasta as directed on the package.
  • While the pasta is cooking, place a large skillet over medium high heat on the stove top. Warm up the olive oil in the skillet and then add the onions and green pepper.
  • Cook for a few minutes until vegetables are tender, then add the mushrooms and garlic. Cook for 1 more minute. Push everything to the side of the pan and add the sausage.
  • Cook the sausage, breaking it into small pieces as it cooks. Cook until it's no longer pink. Drain grease. Add in the pepperoni slices and stir together.
  • Add in remaining ingredients to the skillet except for Mozzarella cheese.
  • Turn the heat down to medium and let the mixture simmer for 2-3 minutes so that the flavors can meld together.
  • Turn off the heat and add the cooked pasta to the skillet pan. Mix everything together.
  • Spray a large 9 x 13 inch baking pan with non-stick cooking spray.
  • Dump the pasta mixture into the pan. Top with Mozzarella cheese and any other toppings you prefer.
  • Bake in the oven (uncovered) for about 30 minutes or until cheese is melted and pasta is heated through.


Some Healthier Options with this recipe include:
  • Protein Pasta
  • Turkey Pepperoni
  • Ground Turkey Sausage
  • Low Fat Mozzarella Cheese


Calories: 389kcal | Carbohydrates: 45g | Protein: 26g | Fat: 12g | Saturated Fat: 5g | Polyunsaturated Fat: 2g | Monounsaturated Fat: 4g | Cholesterol: 68mg | Sodium: 1238mg | Potassium: 776mg | Fiber: 4g | Sugar: 8g | Vitamin A: 604IU | Vitamin C: 35mg | Calcium: 179mg | Iron: 6mg