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5 from 1 vote

John Wayne Casserole (Beef and Biscuit Casserole) Recipe

John Wayne casserole (beef and biscuits casserole), is one of a kind with its taco ingredients and biscuit mix. You do NOT want to pass this up.
Prep Time20 mins
Cook Time30 mins
Total Time50 mins
Course: Main Course
Cuisine: American
Keyword: Best Casserole Recipe, Casserole, easy casserole, john wayne casserole
Servings: 8
Calories: 422kcal


  • 9x13-inch Baking Pan
  • Non-stick Cooking Spray
  • Medium Mixing Bowl (2)
  • Sauté pan


  • 2 pounds ground beef
  • 1 ounce taco seasoning mix 1 package
  • ¾ cup water
  • ½ cup sour cream
  • ½ cup light mayonnaise
  • 1 cup shredded cheddar cheese divided
  • 1 onion diced and divided
  • 2 cups Bisquick biscuit mix
  • 1 cup water
  • 1 green bell pepper diced
  • 2 roma tomatoes diced
  • 4 ounces diced green chilies 1 can


  • Preheat oven to 325 degrees. Spray a 9 x 13 inch baking dish with non-stick cooking spray.
  • Brown ground beef until no longer pink, drain grease. Then add taco seasoning and water and let simmer for 3-4 minutes.
  • In a medium bowl mix sour cream, mayo, half of the cheese, and half of the onion together and set aside.
  • In another bowl, mix together biscuit mix and water to make a soft dough. Press dough into the bottom and 1/2" up the sides of greased 9 x 13 inch pan.
  • Saute remaining onions and green peppers until barely tender.
  • On top of the biscuit, layer the remaining ingredients in this order: ground beef, diced tomatoes, green peppers and onions, green chilies, sour cream mixture, and remaining cheddar cheese.
  • Bake for 30-35 minutes or until edges are slightly browned.


  • Try gluten free Bisquick to make this recipe Gluten Free Friendly


Calories: 422kcal | Carbohydrates: 26g | Protein: 31g | Fat: 21g | Saturated Fat: 9g | Polyunsaturated Fat: 3g | Monounsaturated Fat: 8g | Trans Fat: 1g | Cholesterol: 95mg | Sodium: 953mg | Potassium: 589mg | Fiber: 2g | Sugar: 7g | Vitamin A: 776IU | Vitamin C: 18mg | Calcium: 195mg | Iron: 4mg