Three-Cheese Chicken Penne Pasta Bake

This Three Cheese Chicken Penne Pasta Bake is simple, quick, delicious and full of flavor. If you have picky eaters, they are going to love this pasta dish, we guarantee it.

The other night I babysat all the Kristen’s cute girls, which meant that I had 6 kids under the age of 6.

We usually order pizza when we have everyone over, but I had all the stuff to make this dish, so I threw it together and decided to take a gamble as to if anyone would eat it.

Not only did they each devour it, but they asked for seconds! Such a simple dish, but it’s incredibly delicious.

If you have picky eaters, this is the perfect recipe. It also feeds a crowd, so this is perfect for big families.

could i make this recipe ahead of time?

This recipe is best when served fresh, right out of the oven. However, you could always make it ahead of time and reheat it, or prepare it then wait a little bit to bake it.

We recommend baking it within 24 hours of preparing it. We also don’t recommend serving, then thawing and baking. For best results make and bake immediately, or within 24 hours.

what could i pair this recipe with?

I love pasta. If I could live anywhere in the world, it would probably be Italy, so I could eat homemade pasta day in and day out, for the rest of my life.

Not only that, but they have some amazing bread and sweets there as well.

Here are a few of my favorite side dishes to pair with this pasta dish:

We also love to serve our bread and pasta with salad. Here are a few of our favorite salad recipes:

You could really pair it with any vegetable, but a nice fresh crisp salad with some Italian dressing has got to be my favorite combination with this pasta.

I also like to dip my bread in both the pasta sauce and the salad dressing. You can’t go wrong with salad, pasta, and bread.

watch how to make another delicious pasta dish, here:

Did you know we have a Youtube Channel? We have hundreds of simple and delicious recipes, your family is going to love. We take you through each recipe, step by step, and show you exactly how to make them.

This One Pot Cheesy Chicken Alfredo is so simple and full of flavor. If you are looking for a quick and delicious dinner recipe, we highly recommend this one. Watch how to make it, here:

Looking for more delicious pasta recipes? Here are a few of our favorites:

Serves: 5

Three-Cheese Chicken Penne Pasta Bake

15 minPrep Time

30 minCook Time

45 minTotal Time

Save RecipeSave Recipe


  • 1 1/2 cups penne pasta, uncooked (whole wheat works great)
  • 1 package (9 oz) baby spinach leaves
  • 1 lb. boneless skinless chicken breasts, cut into bite-size pieces
  • 1 teaspoon dried basil leaves
  • 1 (26 oz) jar spaghetti sauce
  • 1 can (14.5 oz) diced tomatoes, drained
  • 2 oz cream cheese, cubed (low fat or fat free works great)
  • 1 cup shredded mozzarella cheese
  • 2 tablespoons grated parmesan cheese


  1. Heat oven to 375 degrees. Cook pasta as directed on package, add spinach to the boiling water the last minute. 
  2. Cook and stir chicken and basil in large nonstick skillet sprayed with cooking spray on medium-heat 3 min.  Stir in spaghetti sauce and tomatoes; bring to boil.  Simmer on low heat for 3 minutes or until chicken is done.  Stir in cream cheese until melted. 
  3. Drain pasta mixture and return to pan. 
  4. Stir in chicken mixture and 1/2 c. mozzarella. 
  5. Spoon into 9x13" casserole baking dish sprayed with non-stick cooking spray. 
  6. Bake 20 minutes; top with remaining cheeses.  Bake for three minutes more or until mozzarella is melted.



2915 cal


42 g


541 g


134 g
Click Here For Full Nutrition, Exchanges, and My Plate Info

Follow Six Sisters’ Stuff on Instagram |Facebook |Pinterest | YouTube

check out our new cookbook

Have you heard about our newest cookbook, Copycat Cooking? We took over 100 of our favorite restaurant recipes and simplified them so that you can make them right at home!

Every recipe has a beautiful mouth-watering photo and has been picky-eater approved. The directions are simple, easy to follow, and do not require any strange ingredients.

This cookbook includes copycat recipes from Wingers, Texas Roadhouse, Starbucks, Panera, Cheesecake Factory, Kneaders, and so much more. We have you covered from drinks, to dessert and everything in-between.

We are so excited to share these recipes with you. Order your copy today!
Six Sisters’ Stuff COPYCAT COOKING <—– Click here to order!

Print Friendly, PDF & Email

Comment on this Recipe

5 Responses to “Three-Cheese Chicken Penne Pasta Bake”

Leave a Reply to Sheila Carlson

Click here to cancel reply.